Study M1029
Study name | Bao CH 2022 |
Title | Moxibustion alleviates depression-like behavior in rats with Crohn's disease by inhibiting the kynurenine pathway metabolism in the gut-brain axis |
Overall design | The aim of this study was to investigate the molecular mechanism by which moxibustion alleviates depressive behavior in rats with Crohn’s disease. The Crohn’s disease rat model was established with 2,4,6-trinitrobenzenesulfonic acid. Sprague-Dawley rats were divided into the following 5 groups (n = 8 in each group): (1) control group, (2) Crohn’s disease model group, (3) Crohn’s disease model + moxibustion group (Crohn’s disease model with moxibustion treatment), (4) Crohn’s disease model + 1-methyltryptophan group (Crohn’s disease model with 1-methyltryptophan treatment), and (5) Crohn’s disease model + moxibustion + 1-methyltryptophan group (Crohn’s disease model with moxibustion and 1-methyltryptophan treatment). Rats in the Crohn’s disease model groups were treated with 2,4,6-trinitrobenzenesulfonic acid. Rats in the moxibustion groups were treated with moxibustion at ST25, CV6, and GV20. Rats in the 1-methyltryptophan groups were intraperitoneally treated with 1-methyltryptophan (10% solution, 1 ml). Kynurenine pathway in the hippocampus were detected by gas chromatography-mass spectrometry (n = 8/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 40 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Bao C, Huang J, Wu H, et al. Moxibustion alleviates depression-like behavior in rats with Crohn's disease by inhibiting the kynurenine pathway metabolism in the gut-brain axis. Front Neurosci. 2022 Dec 7;16:1019590. |
Metabolite | Kynurenine/Tryptophan ratio; |
