Study M1017
Study name | Wang H 2023 |
Title | Disorders in the gut and liver are involved in depression contagion between isosexual post-stroke depression mice and the healthy cohabitors |
Overall design | The aim of this study was to explore whether depressive contagion between post-stroke depression mice and healthy partners involves disturbances in the gut and liver. C57BL/6j mice were divided into the following 3 groups: (1) control group, (2) post-stroke depression group, and (3) healthy control partners pair-housed with post-stroke depression group. Regarding the post-stroke depression mice, after 50 min of cerebral ischemia, they were restrained for 2 h per day for 4 weeks. These mice were pair-housed with a healthy partner for 4 weeks. The results of behavioral tests showed that both post-stroke depression mice and healthy partners pair-housed with post-stroke depression mice displayed depressive-like behaviors. Serum levels of short-chain fatty acids were measured using LC-MS (n =8-10/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6j mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail-suspension test |
Sample size | 27 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: ultimate U3000 Dionex system (Thermo Fisher, Waltham, MA, USA) with triple quadrupole tandem mass spectrometry; |
PMID | |
DOI | |
Citation | Wang H, Wang B, Pan MB, et al. Disorders in the gut and liver are involved in depression contagion between isosexual post-stroke depression mice and the healthy cohabitors. Behav Brain Res. 2022 Dec 6;439:114246. |
Metabolite |
