Study M1009
Study name | Tian PJ 2022b |
Title | Multi-probiotics ameliorate major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation |
Overall design | The aim of this study was to demonstrate the psychotropic potential of probiotics in the chronic unpredictable mild stress (CUMS) model of depression. C57BL/6 mice were divided into the following 3 groups: (1) control group, (2) CUMS group, and (3) CUMS + multi-probiotics group. The CUMS stress procedure lasted for 4 weeks, and multi-probiotics were administered via intragastric once per day during the model building period. For the multi-probiotics, Bifidobacterium breve CCFM1025, Bifidobacterium longum CCFM687, and Pediococcus acidilactici CCFM6432) (1:1:1) were given at a dosage of 10^9 CFU per day. The short-chain fatty acid concentrations in cecal contents were determined by GC-MS (n = 8/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Tian P, Zou R, Wang L, et al. Multi-probiotics ameliorate major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation. J Adv Res. 2022 May 11:S2090-1232(22)00115-1. |
Metabolite |
