Study M1003
Study name | Yang Y 2022 |
Title | Alcohol-soluble polysaccharides from Dendrobium officinale flowers as an antidepressant by regulating the gut-brain axis |
Overall design | The aim of this study was to explore the antidepressant components from Dendrobium officinale flowers aqueous extract and their mechanism in the chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 6 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 10 mg/kg), (4) CUMS + Morinda officinalis oligosaccharide group (stressor plus Morinda officinalis oligosaccharide treatment at the dose of 50 mg/kg), (5) CUMS + low dose of alcohol-soluble polysaccharides group (stressor plus alcohol-soluble polysaccharides treatment at the dose of 65 mg/kg), and (6) CUMS + high dose of alcohol-soluble polysaccharides group (stressor plus alcohol-soluble polysaccharides treatment at the dose of 162 mg/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered daily during the model building period. The short-chain fatty acid concentrations in cecal contents were determined by GC-MS (n = 8/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 48 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Yang Y, Fan L, Peng Y, et al. Alcohol-soluble polysaccharides from Dendrobium officinale flowers as an antidepressant by regulating the gut-brain axis. Int J Biol Macromol. 2022 Sep 1;216:836-849. |
Metabolite |
