Study M1002
Study name | Yang YJ 2022 |
Title | Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice |
Overall design | The aim of this study was to investigate the ameliorative effects of Xiaoyao San on high-fat diet-induced depression and gain insight into its underlying mechanism. C57Bl6/J mice were divided into the following 3 groups: (1) high-fat diet group (high-fat diet), (2) high-fat diet + Xiaoyao San group (high-fat diet plus Xiaoyao San treatment at the dose of 3.9 g/kg), and (3) high-fat diet + Faecalibaculum rodentium group (high-fat diet plus Faecalibaculum rodentium treatment at the dose of 1 x 10^8 CFU). Mice received high-fat diet for 13 weeks, and Xiaoyao San and Faecalibaculum rodentium were administered via intragastric once per day during the last 5 weeks of model building period. Fecal levels of short-chain fatty acids were measured by GC-MS (n =6/group). |
Study Type | Type2; |
Data available | Unavailable |
Organism | Mouse; C57Bl6/J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: GCMS-QP2010 Ultra (Shimadzu); |
PMID | |
DOI | |
Citation | Yang Y, Zhong Z, Wang B, et al. Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice. Biomed Pharmacother. 2022 Dec;156:113902. |
Metabolite |
