Study M083
Study name | Liu LX 2016 |
Title | The identification of metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression |
Overall design | In this study, we used a non-targeted metabolomics approach based on gas chromatography-mass spectrometry of the prefrontal cortex in chronic restraint stress (CRS)-treated rats. CRS was induced in the stress group by restraining rats in a plastic restrainer for 6 h every day. This stress paradigm continued for 3 weeks. Thirty-five rats were divided into 2 groups: (1) control group, (2) CRS group. Eight samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 16 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C GC/MSD System (Agilent Technologies, California, USA); |
PMID | |
DOI | |
Citation | Liu L, Zhou X, Zhang Y, et al. The identification of Metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression. Behav Brain Res 2016;305:148-56. |
Metabolite | myo-Inositol; Stearic acid; Palmitic acid; N-Acetyl-L-aspartic acid; L-Cysteine; L-Proline; L-Glutamic acid; Arachidonic acid; L-Asparagine; L-Glutamine; Threonic acid; Ascorbic acid; Ethanolamine; Uracil; Creatine; Beta-Alanine; Inosine; D-Ribose 5-phosphate; Trehalose 6-phosphate; D-Alanyl-D-alanine; N-Oleoyldopamine; Succinic acid semialdehyde; L-Allothreonine; Lipoamide; D-Tagatose; N-Ethylglycine; Fosfomycin; Maleimide; Octanal; Cuminyl alcohol; |
