Study M077
Study name | Farshim P 2016 |
Title | Maternal weaning modulates emotional behavior and regulates the gut-brain axis |
Overall design | In this study the authors showed that in rats, prevention of weaning from maternal milk results in depressive-like behavior, which is accompanied by changes in the gut bacteria and host metabolism. Depressive-like behavior was studied using the forced-swim test on postnatal day (PND) 25 in rats either weaned on PND 21, or left with their mother until PND 25 (non-weaned). Non-weaned rats showed an increased immobility time consistent with a depressive phenotype. Metabonomic analysis of urine from these animals revealed significant differences in the metabolic profiles, with biochemical phenotypes indicative of depression in the non-weaned animals. In the weaned groups, the mother was taken out of the cage on PND 21, whilst in the non-weaned groups the mother was kept in the cage until PND 25. Rats were randomly divided into 4 groups (n = 6 in each group): (1) non-weaned group, (2) weaned group, (3) non-weaned FST group (non-weaned with forced swim test), (4) weaned FST group (weaned with forced swim test). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 24 |
Tissue | Peripheral; Urine; Urine; |
Platform | NMR; NMR: Bruker Avance III 700 MHz spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Farshim P, Walton G, Chakrabarti B, et al. Maternal weaning modulates emotional behavior and regulates the gut-brain axis. Sci Rep 2016;6:21958. |
Metabolite | Citric acid; Succinic acid; Caproic acid; Dimethylglycine; N1-Methyl-4-pyridone-3-carboxamide; Phenylacetylglycine; Creatinine; Oxoglutaric acid; Taurine; N-acetyl glycoprotein; Betaine; Trimethylamine N-oxide; Acetic acid; Dimethylamine; N-Methylnicotinamide; |
