Study M054

Study name

Chen GH 2015

Title

Amino acid metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression

Overall design

Here, a GC-MS-based metabonomic approach was applied in the chronic unpredictable mild stress (CUMS) model, a well-established rodent model of depression, to investigate significant metabolic changes in the rat prefrontal cortex (PFC). Rats were divided into 2 groups (n = 8 in each group): (1) control group and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks.

Study Type

Type1;

Data available

Unavailable

Organism

Rat; Sprague-Dawley rat;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose preference test

Sample size

16

Tissue

Central; Brain; Prefrontal cortex;

Platform

MS-based; GC-MS: Agilent 7980 GC system with Agilent 5975 mass selective detector (Agilent Technologies Inc., USA);

PMID

24861712

DOI

10.1016/j.bbr.2014.05.027

Citation

Chen G, Yang D, Yang Y, et al. Amino acid Metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression. Behav Brain Res 2015;278:286-92.

Metabolite

Glycerol;

N-Acetyl-L-aspartic acid;

L-Isoleucine;

Beta-Alanine;