Study M052
Study name | Cassol E 2015 |
Title | Altered monoamine and acylcarnitine metabolites in HIV-positive and HIV-negative subjects with depression |
Overall design | In this study, untargeted metabolomic profiling of plasma samples across 3 independent cohorts was performed to investigate metabolic pathways associated with major depressive disorder (MDD) in both HIV-positive and negative subjects. The severity of depressive symptoms was assessed by Beck Depression Inventory (BDI > 14) or Center for Epidemiological Studies Depression Scale (CES-D > 16). Untargeted metabolomic profiling of plasma from 104 subjects (68 HIV-positive and 36 HIV-negative) across 3 independent cohorts was performed using liquid or gas chromatography followed by mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | BDI > 14, CES-D > 16 |
Sample size | 104 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Waters ACQUITY UPLC and Thermo-Finnigan LTQ mass spectrometer; MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Cassol E, Misra V, Morgello S, et al. Altered monoamine and acylcarnitine metabolites in HIV-positive and HIV-negative subjects with depression. J Acquir Immune Defic Syndr 2015;69(1):18-28. |
Metabolite | Propionylcarnitine; p-Hydroxyphenylacetic acid; |
