Study M029
Study name | Ma ZQ 2013 |
Title | Metabonomic study on the antidepressant-like effects of banxia houpu decoction and its action mechanism |
Overall design | The aim of this study was to establish an experimental model for metabonomic profiles of the rat's brain and then to investigate the antidepressant effect of Banxia Houpu decoction (BHD) and its possible mechanisms. Behavioral research and metabonomics method based on UPLC-MS were used to assess the efficacy of different fractions of BHD on chronic unpredictable mild stress (CUMS) model of depression. Rats were divided into three treatment groups as follows: (1) control group, (2) CUMS group, and (3) CUMS + BHD group (stress plus BHD treatment at the dose of 6 g/kg). Three sample per group were used for metabonomic analysis. The CUMS stress procedure lasted for 6 weeks, and BHD was intraperitoneally administered once per day during the last 3 weeks of model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 9 |
Tissue | Central; Brain; Brain; |
Platform | MS-based; LC-MS: Waters Acquity UPLC system with Waters ACQUITY Synapt Q-TOF mass spectrometer (Waters, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Ma Z, Ji W, Qu R, et al. Metabonomic study on the antidepressant-like effects of banxia houpu decoction and its action mechanism. Evid Based Complement Alternat Med 2013:213739. |
Metabolite | Stearic acid; L-Glutamic acid; Glycine; |
