Study M025
Study name | Guo BR 2013 |
Title | [Hippocampus metabonomic study using a CUMS rat model of depression] |
Overall design | The objective of this study was to analysis the regulation of biomarkers by an metabonomic investigation of chronic unpredictable mild stress (CUMS) rats. CUMS induced rat animal depression model, the behavioral changes of rats were observed; meanwhile, hippocampus samples were obtained and subjected to GC-MS analysis to find potential biomarkers of depression. Rats were divided into the following two groups (n = 6 in each group): (1) CUMS group and (2) control group. The CUMS stress procedure lasted for 3 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 12 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; GC-MS: Polaris Q ion trap mass spectrometer (Thermo Fisher Scientific Inc., USA); |
PMID | |
DOI | |
Citation | Guo B, Yang L, Liu J, et al. [Hippocampus metabonomic study using a CUMS rat model of depression]. Chin Pharm J 2013;48(14):1160-4. (Article in Chinese) |
Metabolite | myo-Inositol; Gamma-Aminobutyric acid; |
