Study M006
Study name | Steffens DC 2010 |
Title | Metabolomic differences in heart failure patients with and without major depression |
Overall design | The aim of this study was to determine metabolic differences in depressed and nondepressed participants. The sample consisted of a depressed group of patients with heart failure enrolled in an NIMH-supported clinical trial of sertraline versus placebo in depressed heart failure patients, and a non-depressed comparator group of heart failure patients. Blood samples were obtained from currently depressed individuals (depressed group, n = 40) and non-depressed control participants (control group, n = 40). Plasma samples were profiled on GC-MS and LC-MS metabolomics platforms for biochemical content. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with comorbidity; Depression with comorbidity; |
Criteria for depression | DSM-IV diagnosed MDD, BDI >= 10 |
Sample size | 80 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: Thermo-Finnigan Trace DSQ fastscanning single-quadrupole MS (ThermoElectron Corporation); MS-based; LC-MS: Surveyor High performance liquid chromatography (ThermoElectron Corporation, CA, USA) with LTQ MS (ThermoElectron Corporation); |
PMID | |
DOI | |
Citation | Steffens DC, Jiang W, Krishnan KR, et al. Metabolomic differences in heart failure patients with and without major depression. J Geriatr Psychiatry Neurol 2010;23(2):138-46. |
Metabolite | L-Phenylalanine; L-Leucine; L-Glutamic acid; L-Serine; L-Isoleucine; L-Alanine; L-Aspartic acid; Suberic acid; L-Arginine; Azelaic acid; 3-Hydroxysebacic acid; Sebacic acid; Uridine; L-gamma-glutamyl-L-leucine; Glycyl-Valine; Choline; L-Cystine; Dimethylglycine; L-Kynurenine; Pyroglutamine; D-Arabinose; |
