Study M003
Study name | Wang XY 2009 |
Title | Metabonomics approach to understanding acute and chronic stress in rat models |
Overall design | In this study, a comprehensive analysis of urinary metabolites from SD rats exposed to acute and chronic stimuli was performed to investigate the stress induced biochemical responses and metabolic consequences. Rats were randomly divided into two groups (n= 6 in each group): (1) CUMS group, (2) control group. The CUMS stress procedure lasted for 4 weeks. A twenty-four hour urine sample from each animal was collected at day 0, 9, and 27. Metabolites excreted in urine were analyzed using GC-MS in conjunction with multivariate and univariate statistical techniques. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 12 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; GC-MS: hyphenated Perkin-Elmer gas chromatograph and TurboMass coupled to an Autosystem XL mass spectrometer; |
PMID | |
DOI | |
Citation | Wang X, Zhao T, Qiu Y, et al. Metabonomics approach to understanding acute and chronic stress in rat models. J Proteome Res 2009;8(5):2511-8; Wang X, Zeng C, Lin J, et al. Metabonomics approach to assessing the modulatory effects of St John's wort, ginsenosides, and clomipramine in experimental depression. J Proteome Res 2012;11(12):6223-30. |
Metabolite | Citric acid; Palmitic acid; L-Phenylalanine; L-Tryptophan; L-Valine; L-Proline; L-Glutamic acid; L-Threonine; L-Methionine; L-Glutamine; Homovanillic acid; Hippuric acid; Tyramine; Adipic acid; 4-Aminohippuric acid; |
