Study P160

Study name

Kermorgant M 2021

Title

Cardiac sensory afferents modulate susceptibility to anxio-depressive behaviour in a mouse model of chronic heart failure

Overall design

In this study, chronic heart failure was induced by myocardial infarction. C57BL/6J mice were divided into the following 2 groups: (1) control group (sham myocardial infarction), and (2) myocardial infarction group. The myocardial infarction group showed depression-like behaviors. A proteomic approach was employed on the frontal cortex tissues to identify proteins and pathways that might be responsible for the behavioural allostasis. Proteins with fold changes greater than +/- 2 and with p-values < 0.01 were considered differentially expressed.

Study Type

Type1;

Data available

https://data.mendeley.com/datasets/2kdzsz6s3h/1

Organism

Mouse; C57BL/6J mouse;

Categories of depression

Label free;

Criteria for depression

Tail suspension test, forced swimming test

Sample size

N/A

Tissue

Central; Brain; Frontal cortex;

Platform

Label free;

PMID

33316126

DOI

10.1111/apha.13601

Citation

Kermorgant M, Ben Salem J, Iacovoni JS, et al. Cardiac sensory afferents modulate susceptibility to anxio-depressive behaviour in a mouse model of chronic heart failure. Acta Physiol. 2021 Apr;231(4):e13601.

Protein

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform;

5-hydroxytryptamine receptor 3A;

5'-nucleotidase;

Acyl-coenzyme A thioesterase 13;

Acyl carrier protein, mitochondrial;

Actin-like protein 9;

Disintegrin and metalloproteinase domain-containing protein 17;

Disintegrin and metalloproteinase domain-containing protein 2;

Disintegrin and metalloproteinase domain-containing protein 8;

Adenylate cyclase type 7;

Protein AF-9;

Afamin;

AF4/FMR2 family member 3;

Transcription factor Gibbin;

Apoptosis-inducing factor 1, mitochondrial;

A-kinase anchor protein 13;

Protein ALEX;

Alkylated DNA repair protein alkB homolog 8;

Ankyrin repeat domain-containing protein 10;

Aldehyde oxidase 2;

AP-1 complex subunit gamma-like 2;

AP-1 complex subunit mu-1;

Transcription factor AP-2-alpha;

AP-3 complex subunit beta-1;

Adenomatous polyposis coli protein;

AT-rich interactive domain-containing protein 1A;

AT-rich interactive domain-containing protein 5B;

Arrestin-C;

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2;

Ashwin;

Apoptosis-stimulating of p53 protein 1;

Protein Aster-B;

ATP synthase F(0) complex subunit B1, mitochondrial;

Cyclic AMP-dependent transcription factor ATF-6 beta;

Cysteine protease ATG4D;

Transcription factor Atoh1;

A disintegrin and metalloproteinase with thrombospondin motifs 7;

BAG family molecular chaperone regulator 3;

BCAS3 microtubule associated cell migration factor;

B-cell CLL/lymphoma 9 protein;

D-beta-hydroxybutyrate dehydrogenase, mitochondrial;

Brother of CDO;

Lys-63-specific deubiquitinase BRCC36-like;

Bromodomain-containing protein 8;

Breast cancer metastasis-suppressor 1-like protein;

Coiled-coil and C2 domain-containing protein 1A;

Voltage-dependent P/Q-type calcium channel subunit alpha-1A;

Cadherin-17;

Calretinin;

Calmodulin-like protein 3;

E3 ubiquitin-protein ligase CBL;

Coiled-coil domain-containing protein 116;

Coiled-coil domain-containing protein 27;

Cell division cycle protein 16 homolog;

Cyclin-dependent kinase-like 3;

DNA replication factor Cdt1;

UPF0489 protein C5orf22 homolog;

Protein CEBPZOS;

Major centromere autoantigen B;

Centrosomal protein of 63 kDa;

Cilia- and flagella-associated protein 69;

Uncharacterized protein C7orf57 homolog;

Charged multivesicular body protein 1B2;

Chromodomain-helicase-DNA-binding protein 6;

Charged multivesicular body protein 4c;

Circadian-associated transcriptional repressor;

Cytoskeleton-associated protein 2;

Contactin-associated protein-like 4;

Collagen alpha-2(IX) chain;

Collagen alpha-1(XV) chain;

Collagen alpha-1(XIX) chain;

Centrosomal protein of 135 kDa;

24-hydroxycholesterol 7-alpha-hydroxylase;

Cartilage acidic protein 1;

Caskin-2;

Cationic amino acid transporter 3;

CTD small phosphatase-like protein 2;

Cullin-4B;

Cytochrome c oxidase subunit 7A2, mitochondrial;

C-X-C motif chemokine 15;

Probable ATP-dependent RNA helicase DDX49;

Desmoplakin;

Di-N-acetylchitobiase;

Homeobox protein DLX-5;

Protein dopey-2;

Cilium assembly protein DZIP1L;

Excitatory amino acid transporter 5;

Enoyl-CoA hydratase, mitochondrial;

Early estrogen-induced gene 1 protein;

EF-hand calcium-binding domain-containing protein 5;

Protein EFR3 homolog B;

Egl nine homolog 1;

Early growth response protein 4;

ELAV-like protein 4;

ETS domain-containing protein Elk-4;

Protein ELYS;

Ephrin type-B receptor 1;

Epiplakin;

Eppin;

DNA excision repair protein ERCC-5;

Squalene monooxygenase;

Protein FAM229B;

Coagulation factor VIII;

Protein FAM83G;

Focal adhesion kinase 1;

Protocadherin Fat 4;

F-box/WD repeat-containing protein 10;

F-box/LRR-repeat protein 4;

FYVE, RhoGEF and PH domain-containing protein 6;

Fibroblast growth factor 12;

FH1/FH2 domain-containing protein 3;

Filaggrin;

Forkhead box protein J2;

Forkhead box protein O1;

Forkhead box protein P4;

FERM domain-containing protein 8;

Formimidoyltransferase-cyclodeaminase;

RNA-binding protein FXR2;

Protein GAPT;

Gamma-aminobutyric acid receptor subunit gamma-2;

Ig gamma-2A chain C region, A allele;

Growth/differentiation factor 10;

Growth/differentiation factor 8;

GDNF family receptor alpha-3;

Mitochondrial glutamate carrier 1;

Solute carrier family 2, facilitated glucose transporter member 4;

Guanine nucleotide-binding protein G(olf) subunit alpha;

Golgin subfamily A member 1;

G patch domain-containing protein 8;

Glutamate--cysteine ligase catalytic subunit;

Glutathione S-transferase Mu 5;

Testis-specific H1 histone;

H-2 class II histocompatibility antigen, A-Q alpha chain;

HBS1-like protein;

Ferrochelatase, mitochondrial;

Hormonally up-regulated neu tumor-associated kinase;

Probable imidazolonepropionase;

Hexokinase-1;

Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial;

Interferon-induced protein with tetratricopeptide repeats 2;

Immunoglobulin-binding protein 1b;

Immunoglobulin superfamily DCC subclass member 3;

Interleukin-9 receptor;

INO80 complex subunit B;

InaD-like protein;

Integrator complex subunit 1;

Inositol 1,4,5-trisphosphate receptor-interacting protein;

Intersectin-2;

Izumo sperm-egg fusion protein 2;

Junctional adhesion molecule-like;

Acrosomal protein KIAA1210;

Kallikrein 1-related peptidase b24;

Keratin, type II cytoskeletal 73;

Dyslexia-associated protein KIAA0319-like protein;

Potassium voltage-gated channel subfamily KQT member 2;

Potassium voltage-gated channel subfamily KQT member 4;

BTB/POZ domain-containing protein KCTD4;

Lysine-specific histone demethylase 1A;

Lysine-specific demethylase 5A;

KH domain-containing protein 3;

Kinesin-like protein KIF17;

Kinesin-like protein KIF19;

Krueppel-like factor 2;

Kelch-like protein 41;

Kininogen-1;

Phosphoribosyl pyrophosphate synthase-associated protein 2;

Protein KTI12 homolog;

Putative RNA-binding protein Luc7-like 2;

Lysyl oxidase homolog 3;

Lysyl oxidase homolog 4;

Leucine-rich PPR motif-containing protein, mitochondrial;

Leucine-rich repeat-containing protein 59;

Leucine-rich repeat-containing protein 4;

Leucine-rich repeat and death domain-containing protein 1;

Large subunit GTPase 1 homolog;

Lutropin-choriogonadotropic hormone receptor;

Leucine zipper putative tumor suppressor 3;

Mitochondrial 2-oxoglutarate/malate carrier protein;

Mitogen-activated protein kinase kinase kinase 10;

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB;

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;

Methionine aminopeptidase 2;

Microtubule-associated serine/threonine-protein kinase 1;

Mannose-binding protein C;

Acyl-coenzyme A thioesterase MBLAC2;

MAD2L1-binding protein;

Histone-lysine N-methyltransferase MECOM;

Meiosis-specific with OB domain-containing protein;

Mesoderm posterior protein 1;

Major facilitator superfamily domain-containing protein 6-like;

Mitochondrial intermediate peptidase;

72 kDa type IV collagenase;

Dual specificity mitogen-activated protein kinase kinase 3;

Maestro heat-like repeat-containing protein family member 2B;

ATP-binding cassette sub-family C member 10;

Mucin-15;

NEDD4-binding protein 1;

N-alpha-acetyltransferase 25, NatB auxiliary subunit;

RNA cytidine acetyltransferase;

Cytoplasmic protein NCK2;

Protein NDNF;

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1;

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6;

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9;

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;

N-terminal EF-hand calcium-binding protein 3;

E3 ubiquitin-protein ligase NEDD4-like;

Serine/threonine-protein kinase Nek11;

E3 ubiquitin-protein ligase NEURL1;

Neuroguidin;

Homeobox protein Nkx-2.1;

BOS complex subunit NOMO1;

Neuroplastin;

Oxysterols receptor LXR-beta;

Pro-neuregulin-2, membrane-bound isoform;

Neuropilin-2;

O-acyltransferase like protein;

Opioid growth factor receptor-like protein 1;

Delta-type opioid receptor;

Oxysterol-binding protein-related protein 10;

Serine/threonine-protein phosphatase 4 regulatory subunit 3A;

PAN2-PAN3 deadenylation complex catalytic subunit Pan2;

Poly [ADP-ribose] polymerase 1;

Pre-B-cell leukemia transcription factor 4;

PTB-containing, cubilin and LRP1-interacting protein;

Procollagen C-endopeptidase enhancer 1;

Period circadian protein homolog 2;

PIN2/TERF1-interacting telomerase inhibitor 1;

Piwi-like protein 4;

Pleckstrin homology domain-containing family M member 3;

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon;

Plastin-2;

Nuclear pore membrane glycoprotein 210;

Protein phosphatase 1 regulatory subunit 26;

Protein phosphatase 1 regulatory subunit 29;

PR domain zinc finger protein 1;

Thioredoxin-dependent peroxide reductase, mitochondrial;

Proline-rich protein 32;

Protein PRRC1;

PH and SEC7 domain-containing protein 4;

Adenylosuccinate synthetase isozyme 1;

Cytochrome b-c1 complex subunit 2, mitochondrial;

Ras-related protein Rab-44;

RNA-binding protein 43;

Epidermal retinol dehydrogenase 2;

Regulator of nonsense transcripts 1;

DNA-binding protein Rfx5;

Regulator of G-protein signaling 22;

Rhophilin-2;

Ras and Rab interactor 1;

Large ribosomal subunit protein uL16m;

Large ribosomal subunit protein mL43;

RING finger protein 17;

E3 ubiquitin-protein ligase RNF31;

Ribonuclease H2 subunit A;

E3 ubiquitin-protein ligase TRIM21;

DNA-directed RNA polymerase III subunit RPC7-like;

Runt-related transcription factor 2;

Serum amyloid A-3 protein;

Proactivator polypeptide-like 1;

DNA-binding protein SATB2;

Protein strawberry notch homolog 2;

Polycomb protein SCMH1;

Protein SCO1 homolog, mitochondrial;

Transcriptional repressor scratch 1;

Basic helix-loop-helix transcription factor scleraxis;

Protein SDA1 homolog;

Semaphorin-3E;

Semaphorin-5A;

Semaphorin-6D;

Sentrin-specific protease 3;

Septin-1;

Sideroflexin-5;

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2;

Sperm head and tail associated protein;

Signal-induced proliferation-associated 1-like protein 1;

Small kinetochore-associated protein;

Structural maintenance of chromosomes protein 1B;

Histone-lysine N-methyltransferase Smyd1;

Sorting nexin-17;

Serum response factor;

Signal recognition particle subunit SRP54;

FACT complex subunit SSRP1;

Starch-binding domain-containing protein 1;

Succinate--hydroxymethylglutarate CoA-transferase;

Synaptonemal complex central element protein 2;

Synaptonemal complex protein 2;

Synaptopodin-2;

TSC22 domain family protein 4;

Transcriptional adapter 3;

TBC1 domain family member 10A;

Tubulin beta-6 chain;

TBC1 domain family member 1;

TBC1 domain family member 2A;

T-box transcription factor TBX2;

T-box transcription factor TBX6;

Telomerase reverse transcriptase;

Testis-expressed sequence 37 protein;

Transcription factor IIIB 90 kDa subunit;

Transcription factor p65;

Peroxynitrite isomerase THAP4;

Acyl-coenzyme A thioesterase THEM4;

Transducin-like enhancer protein 3;

Transmembrane protein 145;

Transmembrane protein 160;

Type 2 DNA topoisomerase 6 subunit B-like;

Target of EGR1 protein 1;

Triadin;

TMF-regulated nuclear protein 1;

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2;

NEDD8-conjugating enzyme UBE2F;

Ubiquitin-associated protein 1;

Ubiquitin carboxyl-terminal hydrolase 30;

Ubiquitin carboxyl-terminal hydrolase 47;

E3 UFM1-protein ligase 1;

UDP-glucose:glycoprotein glucosyltransferase 1;

Protein unc-13 homolog C;

General vesicular transport factor p115;

Uronyl 2-sulfotransferase;

Voltage-dependent anion-selective channel protein 3;

Vomeronasal type-1 receptor A8;

Inactive serine/threonine-protein kinase VRK3;

WD repeat-containing protein 44;

WD repeat-containing protein 75;

X-ray radiation resistance-associated protein 1;

3'-5' RNA helicase YTHDC2;

Zinc finger CCCH domain-containing protein 18;

E3 SUMO-protein ligase ZNF451;

Zinc finger protein 638;

Zinc finger-containing ubiquitin peptidase 1;