Study M998
Study name | Li HW 2022 |
Title | Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats |
Overall design | The aim of this study was to explore intestinal microbiota associated with 5-HT metabolism, intestinal immune cells and inflammatory factors in the chronic unpredictable mild stress (CUMS) model of depression. Wistar rats were divided into the following 2 groups (n = 10 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 3 weeks. The content of 5-HT in the hippocampus and prefrontal cortex were measured using HPLC-MS (n = 9/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Li H, Wang P, Zhou Y, et al. Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats. Genes Brain Behav. 2022 Jul;21(6):e12806. |
Metabolite |
