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Study M993

Study name

Romero-Sanchiz P 2019

Title

Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants

Overall design

The aim of this study was to compare the plasma concentrations of oleoylethanolamide and related acylethanolamides in a sample of primary care patients with depression (depression group, n = 69) with those of healthy non-depressed patients (control group, n = 47). Plasma levels of acylethanolamides and monoacylglycerols were detected using liquid chromatography-coupled tandem mass spectrometry system.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

116

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: liquid chromatography with Agilent 6410 triple quadrupole (Agilent Technologies, Wilmington, DE, USA);

PMID

30822499

DOI

10.1016/j.neuropharm.2019.02.026

Citation

Romero-Sanchiz P, Nogueira-Arjona R, Pastor A, et al. Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants. Neuropharmacology. 2019 May 1;149:212-220.

Metabolite

MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0);

Anandamide;

Oleoylethanolamide;

Docosahexaenoyl Ethanolamide;

Linoleoyl ethanolamide;

Palmitoleoylethanolamde;

Docosatetraenylethanolamide;

Dihomo-gamma-linolenoylethanolamide;