Study M987

Study name

Son H 2018a

Title

Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex

Overall design

The aim of this study was to investigate whether glutamate and glutamine levels and glutamatergic neuronal activity are altered in the medial prefrontal cortex (mPFC) of a chronic restraint stress-induced depressive animal model. C57BL/6 mice were divided into the following 2 groups: (1) control group, and (2) chronic restraint stress group. Mice were repeatedly placed in a restrainer for 2 h/day for 15 consecutive days. Amino acid levels in the mPFC, hippocampus and plasma were measured by liquid chromatography mass spectrometry (n = 8/group).

Study Type

Type1;

Data available

Unavailable

Organism

Mouse; C57BL/6 mouse;

Categories of depression

Animal model; Chronic restraint stress model; Chronic restraint stress model;

Criteria for depression

Sucrose preference test, tail suspension test

Sample size

16

Tissue

Central; Brain; Medial prefrontal cortex;

Central; Brain; Hippocampus;

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: Agilent 6460 LC-MS/MS system (Agilent, Singapore);

PMID

30266598

DOI

10.1016/j.neuropharm.2018.09.040

Citation

Son H, Baek JH, Go BS, et al. Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex. Neuropharmacology. 2018 Dec;143:143-152.

Metabolite

L-Glutamic acid;

L-Glutamine;