Study M979
Study name | Sun YZ 2022 |
Title | Shuangxinfang prevents S100A9-induced macrophage/microglial inflammation to improve cardiac function and depression-like behavior in rats after acute myocardial infarction |
Overall design | The aim of this study was to explore the biological mechanism of Shuangxinfang in depression after cardiac function. Sprague-Dawley rats were divided into the following 4 groups: (1) control group (sham operation), (2) acute myocardial infarction group (acute myocardial infarction operation), (3) acute myocardial infarction + Shuangxinfang group (acute myocardial infarction operation with Shuangxinfang treatment at the dose of 1 ml/100 g/d), and (4) acute myocardial infarction + ABR-215757 group (acute myocardial infarction operation with ABR-215757 treatment at the dose of 5 mg/kg/d). Ligation of the left anterior descending coronary artery was used to construct the acute myocardial infarction rat model, and drugs were administered via intragastric for 5 days. The hippocampus tissues were analyzed to examine the effects of acute myocardial infarction on neurotransmitters in the brain by liquid chromatography-mass spectrometry (n = 3/per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 12 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Waters ACQUITY UPLC I with AB SCIEX QTRAP 4500 (United States) triple quadrupole mass spectrometer; |
PMID | |
DOI | |
Citation | Sun Y, Wang Z, Hou J, et al. Shuangxinfang prevents S100A9-induced macrophage/microglial inflammation to improve cardiac function and depression-like behavior in rats after acute myocardial infarction. Front Pharmacol. 2022 Jun 24;13:832590. |
Metabolite |
