Study M974
Study name | Zhu YY 2022b |
Title | Transcranial ultrasound stimulation relieves depression in mice with chronic restraint stress |
Overall design | The aim of this study was to investigate the effects of transcranial ultrasound stimulating the dorsal raphe nucleus on antidepressant-like behaviors in mice. C57BL/6 mice were divided into the following 3 groups: (1) control group, (2) CRS group (CRS stress with sham transcranial ultrasound stimulating), and (3) CRS + transcranial ultrasound stimulating group (CRS stress with transcranial ultrasound stimulating). The CRS stress procedure lasted for 3 weeks (4 hours per day), then a head-mounted fixture was fixed on the skull of each successful mouse model by surgery. After one week of recovery, ultrasound stimulation was applied to freely behaving mice in the transcranial ultrasound stimulating group for 3 weeks. Liquid chromatography-mass spectrometry is performed to quantitatively detect the concentration of serotonin in the dorsal raphe nucleus. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Sucrose preference test, tail suspension test |
Sample size | 14 |
Tissue | Central; Brain; Dorsal raphe nucleus; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Zhu Y, He J, Wu C, et al. Transcranial ultrasound stimulation relieves depression in mice with chronic restraint stress. J Neural Eng. 2022 Aug 23. |
Metabolite |
