Study M973
Study name | Zhao H 2022 |
Title | Variation in thyroid-stimulating hormone and cognitive disorders in unmedicated middle-aged patients with major depressive disorder: a proton magnetic resonance spectroscopy study |
Overall design | The aim of this study was to investigate possible changes in prefrontal cortex and cerebellar biochemical metabolism in middle-aged patients with major depressive disorder (MDD). N-acetyl aspartate/creatine (Cr) and choline/Cr ratios in the prefrontal cortex and cerebellum were obtained via proton magnetic resonance spectroscopy from 30 first-episode, untreated middle-aged patients with MDD (MDD group) and 30 well-matched healthy controls (control group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-24 >= 20 |
Sample size | 60 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Cerebellum; |
Platform | MRS; MRS: Discovery MR750 3.0-T System (General Electric, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Zhao H, Lai S, Zhong S, et al. Variation in thyroid-stimulating hormone and cognitive disorders in unmedicated middle-aged patients with major depressive disorder: a proton magnetic resonance spectroscopy study. Mediators Inflamm. 2022 Sep 5;2022:1623478. |
Metabolite |
