Study M971
Study name | Zhang XP 2022 |
Title | Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders |
Overall design | The aim of this study was to explore the effective targets of Tao-Hong-Si-Wu decoction in the chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 6 groups (n = 8 in each group): (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 10 mg/kg), (4) CUMS + low dose of Tao-Hong-Si-Wu decoction group (stressor plus Tao-Hong-Si-Wu decoction treatment at the dose of 2.5 g/kg), (5) CUMS + middle dose of Tao-Hong-Si-Wu decoction group (stressor plus Tao-Hong-Si-Wu decoction treatment at the dose of 5 g/kg), and (6) CUMS + high dose of Tao-Hong-Si-Wu decoction group (stressor plus Tao-Hong-Si-Wu decoction treatment at the dose of 10 g/kg). A serum metabolomics method was applied to reveal discriminant metabolites and varied metabolic pathways associated with CUMS modelling and the effect of Tao-Hong-Si-Wu decoction on depression-like symptoms. The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric for 2 weeks after the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test |
Sample size | 46 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; GC-MS: Shimadzu GC-MS 2010 (Kyoto, Japan); |
PMID | |
DOI | |
Citation | Zhang X, Li Z, Shen C, et al. Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders. Pharm Biol. 2022 Dec;60(1):1739-1750. |
Metabolite | myo-Inositol; Citric acid; 3-Hydroxybutyric acid; L-Phenylalanine; L-Valine; L-Proline; L-Glutamic acid; Glycine; L-Serine; L-Lactic acid; L-Alanine; L-Lysine; L-Tyrosine; D-Glucose; Pseudouridine; Urea; 4-Hydroxyproline; Glycolic acid; Dopamine; Ornithine; Sucrose; 3-Aminoisobutanoic acid; Phenylacetic acid; Phosphate; Arachidic acid; Propionic acid; |
