Study M970
Study name | Zhang T 2022 |
Title | Alterations of plasma lipids in adult women with major depressive disorder and bipolar depression |
Overall design | The aim of this study was to identify peripheral biomarkers for major depressive disorder (MDD) and bipolar depression (BPD). Age-matched female individuals with MDD (MDD group, n = 28), BPD (BPD group, n = 22) and healthy controls (control group, n = 25) were enrolled. Plasma samples were analyzed by comprehensive lipid profiling based on liquid chromatography-mass spectrometry (LC/MS). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD |
Sample size | 53 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: UHPLC Nexera LC-30A ultra-highperformance liquid chromatography system with Q-Exactive Plus (Thermo Fisher Scientific, United States); |
PMID | |
DOI | |
Citation | Zhang T, Guo L, Li R, et al. Alterations of plasma lipids in adult women with major depressive disorder and bipolar depression. Front Psychiatry. 2022 Jul 18;13:927817. |
Metabolite | Cer(d18:1/24:0); Cer(d18:1/16:0); Cer(d18:1/24:1); PC(40:4); S-Adenosylmethionine; Cer(d18:1/24:2); LysoPE(20:5); PI(16:0/20:4); PC(44:5); Phosphatidylinositol; PC(18:0/16:0); PC(40:10); LysoPC(17:1); Cer(d18:2/23:0); GM2; CerP(d15:0/14:0+O); DGDG(47:12e); GM2(d34:5); GM3(t39:6); LysoPE(18:2e); PC(14:1e/23:1); Cer(d32:4); PC(20:0e/22:4); PC(20:1e/18:2); PC(26:2e); PC(39:5); PC(8:0e/6:0); PE(18:0/16:0); PE(20:0p/22:6); PG(36:0/8:0); TG(16:0/16:1/22:6); TG(16:0/20:4/22:5); TG(17:0/18:2/20:5); TG(18:1/18:2/18:3); TG(18:1/18:2/22:4); TG(18:2/17:1/18:2); TG(18:3/18:2/18:3); TG(18:3/18:2/20:3); TG(18:3/18:3/20:5); TG(18:3/20:4/20:4); TG(20:0/18:1/18:1); TG(22:4/17:1/18:2); CerG2GNAc1(d32:1); CerG2GNAc1(d36:1); CerG2GNAc1(d38:4); Monogalactosyldiacylglycerol; Phytosphingomyelin; CeramideG2GNAc1; Phosphatidylserine; CerG2GNAc1(m30:1); CerG2GNAc1(t33:2); Cer(d15:1/25:2); Cer(d17:1/24:1); AcCa(14:2); PC(16:0/22:0); PC(16:2e/20:3); Cer(d19:1/24:0); Cer(d38:0); Cer(d40:1); Cer(d40:3); Cer(d41:1+O); PG(28:0/18:2); PI(16:1); SM(d36:4); Cer(m19:1/23:0+O); |
