Study M967
Study name | Xiao WP 2022b |
Title | Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: a benefit of short chain fatty acids |
Overall design | The aim of this study was to investigate whether gut microbiota-derived short chain fatty acid metabolism is involved in the progression of vascular depression. Sprague-Dawley rats were divided into the following 2 groups: (1) control group (sham operation), and (2) bilateral common carotid artery occlusion group. Compared to the control group, rats in the bilateral common carotid artery occlusion group showed a reduced preference toward sucrose at day 15 post-surgery. Blood samples were collected from the rats 21 d post-surgery for short chain fatty acid analysis using gas chromatography-mass spectrometry (n= 6/per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 12 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; GC-MS: 7890 GC–MS/MS (Agilent Technologies Inc.); |
PMID | |
DOI | |
Citation | Xiao W, Li J, Gao X, et al. Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: a benefit of short chain fatty acids. Exp Neurol. 2022 Dec;358:114225. |
Metabolite |
