Study M963
Study name | Spurny-Dworak B 2022 |
Title | The impact of theta-burst stimulation on cortical GABA and glutamate in treatment-resistant depression: a surface-based MRSI analysis approach |
Overall design | The aim of this study was to expand insights into the therapeutic effects of theta burst stimulation on the GABAergic and glutamatergic system utilizing 3D-multivoxel magnetic resonance spectroscopy imaging (MRSI) in combination with a novel surface-based MRSI analysis approach to investigate changes of cortical neurotransmitter levels in patients with treatment-resistant depression. Twelve treatment-resistant depression patients completed paired MRSI measurements, using a GABA-edited 3D-multivoxel MEGA-LASER sequence, before and after 3 weeks of bilateral theta burst stimulation treatment. Changes in cortical distributions of GABA+/tNAA (GABA+macromolecules relative to total Nacetylaspartate) and Glx/tNAA (Glx = mixed signal of glutamate and glutamine), were investigated in a surface-based region-of-interest (ROI) analysis approach. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 18, Clinical Global Impression Scale score >= 4 |
Sample size | 12 |
Tissue | Central; Brain; Cortex; |
Platform | MRS; MRS: 3 Tesla MAGNETOM Prisma Siemens MR Scanner; |
PMID | |
DOI | |
Citation | Spurny-Dworak B, Godbersen GM, Reed MB, et al. The impact of theta-burst stimulation on cortical GABA and glutamate in treatment-resistant depression: a surface-based MRSI analysis approach. Front Mol Neurosci. 2022 Jul 13;15:913274. |
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