Study M960
Study name | Pavlova I 2022 |
Title | Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: a pilot study |
Overall design | The aim of this study was to assess the brain metabolic state in the olfactory bulbectomy induced depression model. Wistar rats were divided into the following 2 groups: (1) control group (sham operation, n = 9), and (2) olfactory-bulbectomised group (bilateral ablation of the olfactory bulbs, n = 10). Three weeks after surgery, proton magnetic resonance spectroscopy was used to measure relative metabolite concentrations in the cortex and hippocampus. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Not reported |
Sample size | 19 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Cortex; |
Platform | MRS; MRS: 9.4 T Bruker NMR small animal system (Bruker BioSpec 94/30 USR); |
PMID | |
DOI | |
Citation | Pavlova I, Drazanova E, Kratka L, et al. Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: a pilot study. World J Biol Psychiatry. 2022 Sep 28:1-15. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
