Study M958
Study name | MahmoudianDehkordi S 2022 |
Title | Gut microbiome-linked metabolites in the pathobiology of major depression with or without anxiety-a role for bile acids |
Overall design | The aim of this study was to examine whether bile acids at baseline were different in treatment-naive outpatients with major depressive disorder (MDD) who responded to treatment vs. those who did not respond to treatment after 12 weeks of treatment/therapy. Using targeted metabolomics, primary and secondary bile acids were profiled in the baseline serum samples of 208 untreated outpatients with MDD. Then the levels of these metabolites were compared between participants who responded to treatment (remitter group; n = 73) vs. those who did not respond to treatment (non-remitter group; N = 25) after 12 weeks of treatment/therapy. |
Study Type | Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >=15 |
Sample size | 98 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: ultraperformance liquid chromatography triple quadrupole mass spectrometry (Waters XEVO TQ-S, Milford, USA); |
PMID | |
DOI | |
Citation | MahmoudianDehkordi S, Bhattacharyya S, Brydges CR, et al. Gut microbiome-linked metabolites in the pathobiology of major depression with or without anxiety-a role for bile acids. Front Neurosci. 2022 Jul 20;16:937906. |
Metabolite | Chenodeoxycholic acid; Isolithocholic acid; Chenodeoxycholic acid/Cholic acid ratio; Nutriacholic acid/Chenodeoxycholic acid ratio; Glycohyocholic acid/Chenodeoxycholic acid ratio; 3a,6a,7b-Trihydroxy-5b-cholanoic acid/Chenodeoxycholic acid ratio; Dehydrolithocholic acid/Chenodeoxycholic acid ratio; Lithocholic acid 3-O-sulfate/Chenodeoxycholic acid ratio; Lithocholic acid glycine conjugate/Isolithocholic acid ratio; |
