Study M949
Study name | Jin Y 2022 |
Title | Ginseng total saponins and Fuzi total alkaloids exert antidepressant-like effects in ovariectomized mice through BDNF-mTORC1, autophagy and peripheral metabolic pathways |
Overall design | The aim of this study was to elucidate the antidepressant-like effects of ginseng total saponins and Fuzi total alkaloids compatibility in the bilateral ovariectomy model of menopausal depression. Female ICR mice were divided into the following 6 groups: (1) control group (sham bilateral ovariectomy), (2) ovariectomy group (bilateral ovariectomy), (3) ovariectomy + low dose of Ginseng total saponins and Fuzi total alkaloids group (bilateral ovariectomy, with Ginseng total saponins, 10 mg/kg/d, and Fuzi total alkaloids, 3.75 mg/kg/d), (4) ovariectomy + middle dose of Ginseng total saponins and Fuzi total alkaloids group (bilateral ovariectomy, with Ginseng total saponins, 33 mg/kg/d, and Fuzi total alkaloids, 12.38 mg/kg/d), (5) ovariectomy + high dose of Ginseng total saponins and Fuzi total alkaloids group (bilateral ovariectomy, with Ginseng total saponins, 100 mg/kg/d, and Fuzi total alkaloids, 37.53 mg/kg/d), and (6) ovariectomy + fluoxetine group (bilateral ovariectomy, with fluoxetine treatment at a dose of 10 mg/kg/d). Seven days after recovery from ovariectomy, immobility time increased significantly, and drugs were then administered via intragastric once per day for 7 days. Ten serum samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 60 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Dionex Ultimate 3000 RS UPLC system with Q-Exactive quadrupole-Orbitrap mass spectrometer; |
PMID | |
DOI | |
Citation | Jin Y, Pang H, Zhao L, et al. Ginseng total saponins and Fuzi total alkaloids exert antidepressant-like effects in ovariectomized mice through BDNF-mTORC1, autophagy and peripheral metabolic pathways. Phytomedicine. 2022 Dec;107:154425. |
Metabolite | Cer(d18:0/16:0); 3,4,5-trihydroxy-6-{[(2E)-2-methyl-3-phenylprop-2-en-1-yl]oxy}oxane-2-carboxylic acid; 5,7-dihydroxy-2-(1-hydroxy-3,5-dimethoxy-4-oxocyclohex-2-en-1-yl)-4H-chromen-4-one; (2Z)-3-phenyl-2-[(sulfooxy)methyl]prop-2-enoic acid; 4-Vinylphenol sulfate; 6-(4-ethyl-2-hydroxyphenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid; (9S,10S)-9,10-dihydroxyoctadecanoate; PE(14:0/22:5(4Z,7Z,10Z,13Z,16Z)); PA(15:0/20:2(11Z,14Z)); PA(18:0/18:2(9Z,12Z)); PA(P-18:0/17:2(9Z,12Z)); |
