Study M946
Study name | Hirtz R 2022b |
Title | Age at menarche relates to depression in adolescent girls: comparing a clinical sample to the general pediatric population |
Overall design | The aim of this study was to investigate depression severity in relation to pubertal timing and multiple gonadal and adrenal steroid hormones determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) based on a large psychiatric sample of girls with significant depressive symptoms. A total of 184 patients (with a total BDI-II score above 13, depression group) and 59 subjects from the reference cohort (control group) were included for analysis. Serum gonadal/adrenal hormones (progesterone, androstenedione, testosterone, dihydrotestosterone, cortisol) were determined by liquid chromatography-tandem mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | BDI-II > 13 |
Sample size | 243 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Waters Acquity UPLC System (Waters, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Hirtz R, Libuda L, Hinney A, et al. Age at menarche relates to depression in adolescent girls: comparing a clinical sample to the general pediatric population. J Affect Disord. 2022 Dec 1;318:103-112. |
Metabolite |
