Study M945
Study name | Hirtz R 2022a |
Title | The adrenal steroid profile in adolescent depression: a valuable bio-readout? |
Overall design | The aim of this study was to assess whether adrenal steroids serve as biomarkers for adolescent major depressive disorder (MDD). A total of 261 psychiatric patients (MDD group) and 255 subjects from the reference cohort (control group) were included for analysis. Serum adrenal steroids (progesterone, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, deoxycorticosterone, corticosterone) were determined by liquid chromatography-tandem mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD or clinical assessment |
Sample size | 516 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Waters Quattro Premier/Xe triple-quadrupole mass spectrometer (Waters, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Hirtz R, Libuda L, Hinney A, et al. The adrenal steroid profile in adolescent depression: a valuable bio-readout? Transl Psychiatry. 2022 Jun 18;12(1):255. |
Metabolite | Corticosterone; Cortisol; Progesterone; Cortisol/Cortisone ratio; Cortexolone; Deoxycorticosterone; Cortisone; 17-Hydroxyprogesterone; |
