Study M937

Study name

Akiyama S 2022

Title

Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice

Overall design

The aim of this study was to examine the effects of chronic social defeat stress on multiple synthetic pathways of lipid mediators in brain regions associated with stress susceptibility in chronic social defeat stress model of depression. In the first study, C57BL/6N mice were divided into 3 groups: (1) control group, (2) stress-susceptible group, and (3) stress-resilient group. The chronic social defeat stress procedure lasted for 10 days, then stressed mice were divided into stress-susceptible and stress-resilient groups based on the results of social interaction test. Then blood and brain tissues were collected for lipid metabolite analyses. In the second study, C57BL/6N mice were intraperitoneally injected with imipramine (20 mg/kg, imipramine group) or with saline (saline group) and subjected to the forced swim test 30 min later. Then lipid metabolites in the nucleus accumbens were measured.

Study Type

Type1;

Type3;

Data available

Unavailable

Organism

Mouse; C57BL/6N mouse;

Categories of depression

Animal model; Social defeat model; Social defeat model;

Criteria for depression

Social interaction test

Sample size

47

Tissue

Peripheral; Blood; Plasma;

Central; Brain; Prefrontal cortex;

Central; Brain; Amygdala;

Central; Brain; Hippocampus;

Central; Brain; Nucleus accumbens;

Central; Brain; Dorsal striatum;

Platform

MS-based; LC-MS: not reported;

PMID

35790870

DOI

10.1038/s41598-022-15461-7

Citation

Akiyama S, Nagai H, Oike S, et al. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice. Sci Rep. 2022 Jul 5;12(1):11385.

Metabolite

12-HETE;

12-HEPE;