Study M929

Study name

Li D 2022a

Title

3beta-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males

Overall design

The aim of this study was to evaluate the relationships among testosterone deficiency, depression, and the gut microbiota. Patients who met the diagnostic criteria for major depressive disorder (MDD) or dysthymic disorder were included in the depression group (depression group, n = 77). Healthy participants were included in the non-depression group (control group, n = 102). Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was conducted to quantify the serum testosterone levels in the 2 groups.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD or dysthymic disorder

Sample size

179

Tissue

Peripheral; Blood; Serum;

Platform

MS-based; LC-MS: Ekspert ultraLC 100-XL system (AB SCIEX, Framingham, MA, USA) with AB SCIEX 4500 QTRAP mass spectrometer;

PMID

35108497

DOI

10.1016/j.chom.2022.01.001

Citation

Li D, Liu R, Wang M, et al. 3beta-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males. Cell Host Microbe. 2022 Mar 9;30(3):329-339.e5.

Metabolite

Testosterone;