Study M925
Study name | He JL 2022 |
Title | Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder |
Overall design | The aim of this study was to investigate the characteristics of working memory and neurometabolic changes in patients with obsessive-compulsive disorder and major depressive disorder. A total of 32 unmedicated MDD patients (MDD group) and 33 healthy controls (control group) were included. All subjects underwent protons magnetic resonance spectroscopy to collect neurometabolic ratios of N-acetyl aspartate and choline-containing compounds in the prefrontal cortex and lentiform nucleus. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD, HAMD-24 > 20 |
Sample size | 65 |
Tissue | Central; Brain; Lentiform nucleus; Central; Brain; Prefrontal cortex; |
Platform | MRS; MRS: 3.0 T GE magnetic resonance system (Discovery MR 750 system, General Electric, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | He J, Yan S, Song Z, et al. Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder. J Affect Disord. 2022 May 16;311:556-564. |
Metabolite |
