Study M921
Study name | Linghu T 2022 |
Title | Novel targets for ameliorating energy metabolism disorders in depression through stable isotope-resolved metabolomics |
Overall design | The aim of this study was to investigate the disturbance of energy metabolism in the chronic unpredictable mild stress (CUMS) model of depression through stable isotope-resolved metabolomics. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. The liver samples were used for stable isotope-resolved metabolomics (n =10/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 20 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: Dionex UltiMate 3000 UPLC system with Q Exactive mass spectrometer (Thermo Fisher Scientifc Inc., Germany); |
PMID | |
DOI | |
Citation | Linghu T, Zhao Y, Wu W, et al. Novel targets for ameliorating energy metabolism disorders in depression through stable isotope-resolved metabolomics. Biochim Biophys Acta Bioenerg. 2022 May 28;1863(7):148578. |
Metabolite | L-Glutamic acid; L-Serine; L-Lactic acid; L-Alanine; L-Glutamine; L-Aspartic acid; D-Glucose; |
