Study M916
Study name | Duan LH 2022 |
Title | Metabolomics analysis of the prefrontal cortex in a rat chronic unpredictable mild stress model of depression |
Overall design | The aim of this study was to explore the pathophysiology of the prefrontal cortex (PFC) in a chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 2 groups (n = 9 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. High-performance liquid chromatography-tandem mass spectrometry was applied to test metabolites in rat PFC. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; LC-MS: 1260 Infinity liquid chromatograph (Agilent J & W Scientific, Folsom, CA, USA) with Q-Exactive MS/MS (Thermo, MA, USA); |
PMID | |
DOI | |
Citation | Duan L, Fan R, Li T, et al. Metabolomics analysis of the prefrontal cortex in a rat chronic unpredictable mild stress model of depression. Front Psychiatry. 2022 Mar 15;13:815211. |
Metabolite | 1-Methylnicotinamide; 3-Methylhistidine; |
