Study M914
Study name | Bonnekoh LM 2022 |
Title | Long-term cortisol stress response in depression and comorbid anxiety is linked with reduced N-acetylaspartate in the anterior cingulate cortex |
Overall design | The aim of this study was to investigate metabolic alterations in the anterior cingulate cortex of patients with major depression (MDD). We investigated 22 patients with MDD and comorbid anxiety disorder (depression with anxiety group) and 23 healthy controls (control group). Proton magnetic resonance spectroscopy was performed with voxels placed in pregenual and dorsal cingulate cortex in 3T. Metabolite quantification was reported relative to total creatine as the reference peak. Analysis of hair cortisol was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Currently or previously DSM-IV-TR diagnosed MDD |
Sample size | 45 |
Tissue | Peripheral; Hair; Hair; Central; Brain; Pregenual anterior cingulate cortex; Central; Brain; Dorsal anterior cingulate cortex; |
Platform | MRS; MRS: 3 Tesla MRI scanner (Siemens MAGNETOM Prisma, Erlangen, Germany); MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Bonnekoh LM, Seidenbecher S, Knigge K, et al. Long-term cortisol stress response in depression and comorbid anxiety is linked with reduced N-acetylaspartate in the anterior cingulate cortex. World J Biol Psychiatry. 2022 Mar 25:1-35. |
Metabolite |
