Study M910
Study name | Cenik B 2022 |
Title | Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone |
Overall design | The aim of this study was to measure total cholesterol and sterol concentrations with mass spectrometry in postmortem brain samples from depressed and control subjects. Concentrations of sterols were measured in prefrontal cortex and cerebellum samples from 20 depressed subjects (depression group) and 20 controls (control group). The concentrations of 19 sterols were measured using LC-MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM diagnosed MDD |
Sample size | 40 |
Tissue | Central; Brain; Cerebellum; Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Cenik B, Palka JM, Thompson BM, et al. Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone. Transl Psychiatry. 2022 Apr 4;12(1):139. |
Metabolite |
