Study M905

Study name

Zhao SG 2022

Title

Brain functional network and amino acid metabolism association in females with subclinical depression

Overall design

The aim of this study was to investigate the association between complex brain functional networks and the metabolites in urine in subclinical depression. Electroencephalography (EEG) signals were recorded from 78 female college students, including 40 with subclinical depression (subclinical depression group) and 38 healthy controls (control group). The urine of all participants was collected for non-targeted LC-MS metabolic analysis to screen differential metabolites.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom; Depressive symptom;

Criteria for depression

Beck Depression Scale-II scores between 14 and 27

Sample size

78

Tissue

Peripheral; Urine; Urine;

Platform

MS-based; LC-MS: UHPLC system (1290, Agilent Technologies, Santa Clara, CA, USA) with Q Exactive (Orbitrap MS, Thermo);

PMID

35329007

DOI

10.3390/ijerph19063321

Citation

Zhao S, Khoo S, Ng SC, et al. Brain functional network and amino acid metabolism association in females with subclinical depression. Int J Environ Res Public Health. 2022 Mar 11;19(6):3321.

Metabolite

L-Phenylalanine;

L-Lactic acid;

Azelaic acid;

Dimethylglycine;

3-Hydroxyhippuric acid;

5'-Methylthioadenosine;

Isobutyric acid;

Glycoursodeoxycholic acid;

Gentisic acid;

Dihydrothymine;

3,4-Dihydroxyhydrocinnamic acid;

3-Methyluridine;

m-Cresol;

Vanillin;

Cortisone;

Indole-3-carbinol;

4-Ethylbenzoic acid;

Formylanthranilic acid;

17a-Ethynylestradiol;

1,3-Dimethyluracil;

Ammonia;

Glycyl-Phenylalanine;

2,4,6-Trihydroxybenzoic acid;

4-Hydroxy-3-methylbenzoic acid;