Study M902
Study name | Lai WD 2022 |
Title | Fish oil ameliorates neuropsychiatric behaviors and gut dysbiosis by elevating selected microbiota-derived metabolites and tissue tight junctions in rats under chronic sleep deprivation |
Overall design | The aim of this study was to investigate the effect of fish oil on neuropsychiatric behaviors, barrier injury, microbiota dysbiosis, and microbiota-derived metabolites in sleep deprivation rats. Wistar rats were divided into the following 3 groups (n = 8 in each group): (1) control group, (2) sleep deprivation group, and (3) sleep deprivation + fish oil group. A 6-week dietary intervention (oil normal diet or fish oil-rich diet) was initiated, followed by 4-week chronic sleep deprivation. The fecal concentrations of secondary bile acids were determined by ultra-high-performance liquid chromatography-mass spectrometer (n =8/per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sleep deprivation induced depression model |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: Waters ultra-high-performance liquid chromatography system coupled with Waters Xevo TQS MS (Waters Corp); |
PMID | |
DOI | |
Citation | Lai WD, Tung TH, Teng CY, et al. Fish oil ameliorates neuropsychiatric behaviors and gut dysbiosis by elevating selected microbiota-derived metabolites and tissue tight junctions in rats under chronic sleep deprivation. Food Funct. 2022 Mar 7;13(5):2662-2680. |
Metabolite |
