Study M901
Study name | Sun YY 2020 |
Title | Antidepressant-like effects of Schisandrin on lipopolysaccharide-induced mice: Gut microbiota, short chain fatty acid and TLR4/NF-kB signaling pathway |
Overall design | The aim of this study was to research the potential connection between gut microbial and anti-inflammatory effects of Schisandrin on a depressive mouse model induced by lipopolysaccharide (LPS). C57BL/6 mice were divided into the following 3 groups (n = 12 in each group): (1) control group, (2) LPS group, and (3) LPS + Schisandrin group. Mice were treated with vehicle or Schisandrin (30 mg/kg, intraperitoneally) for 14 days. In the 14th day, LPS (0.83 mg/kg) or saline were intraperitoneally injected 30 min after drug administration. The concentrations of short-chain fatty acids in mice fecal samples were analyzed (n = 6/per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 18 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: GCMSTQ8040 (Agilent, USA); |
PMID | |
DOI | |
Citation | Sun Y, Yan T, Gong G, et al. Antidepressant-like effects of Schisandrin on lipopolysaccharide-induced mice: Gut microbiota, short chain fatty acid and TLR4/NF-kB signaling pathway. Int Immunopharmacol. 2020 Dec;89(Pt A):107029. |
Metabolite |
