Study M899

Study name

Zhang YL 2022

Title

Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury

Overall design

The aim of this study was to examine the executive function and biochemical metabolism alterations, as well as to elucidate their associations in depressed adolescents with non-suicidal self-injury. A total of 86 adolescents with major depressive disorder, including 40 with non-suicidal self-injury (depression with non-suicidal self-injury group), and 46 without non-suicidal self-injury (depression without non-suicidal self-injury group) and 28 healthy controls (control group) were recruited in the current study. Bilateral metabolite levels of the prefrontal cortex, anterior cingulated cortex, lenticular nucleus of basal ganglia and thalamus were obtained by 1H-MRS at 3.0 T. The ratios of N-acetyl aspartate and choline-containing compounds to creatine were determined.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Pediatric depression; Pediatric depression;

Criteria for depression

DSM-5 diagnosed MDD, HAMD-24 >= 20

Sample size

114

Tissue

Central; Brain; Anterior cingulate cortex;

Central; Brain; Prefrontal cortex;

Central; Brain; Lenticular nucleus;

Central; Brain; Thalamus;

Platform

MRS; MRS: 3.0 T GE MR system (Discovery MR 750 System, GE Healthcare, Milwaukee, WI);

PMID

34737017

DOI

10.1016/j.jad.2021.10.132

Citation

Zhang Y, Lai S, Wu W, et al. Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury. J Affect Disord. 2022 Feb 1;298(Pt A):492-499.

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;