Study M895

Study name

Miao HF 2022

Title

Childhood trauma history is linked to abnormal brain metabolism of non-medicated adult patients with major depressive disorder

Overall design

The aim of this study was to investigate the neurometabolic changes in unmedicated major depressive disorder (MDD) patients who had experienced childhood trauma. In this study, unmedicated MDD patients with childhood trauma (MDD with childhood trauma group, n = 37), unmedicated MDD patients without childhood trauma (MDD without childhood trauma group, n = 35), and healthy control participants (control group, n = 30) underwent high-resolution proton magnetic resonance spectroscopy examination. Bilateral metabolic ratios of N-acetylaspartate/creatine and choline/creatine in the prefrontal white matter, anterior cingulate cortex, putamen, and cerebellum were obtained.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-5 diagnosed MDD, HAMD-24 >= 20

Sample size

102

Tissue

Central; Brain; Prefrontal white matter;

Central; Brain; Cerebellum;

Central; Brain; Putamen;

Central; Brain; Anterior cingulate cortex;

Platform

MRS; MRS: Discovery MR 750 3.0T MRI scanner (General Electric, Milwaukee, WI, USA);

PMID

34965400

DOI

10.1016/j.jad.2021.12.103

Citation

Miao H, Zhong S, Liu X, et al. Childhood trauma history is linked to abnormal brain metabolism of non-medicated adult patients with major depressive disorder. J Affect Disord. 2022 Apr 1;302:101-109.

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;