Study M889
Study name | Dai GL 2021 |
Title | [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus] |
Overall design | The aim of this study was to investigate the effects and mechanisms of Jiaotai Pills on depressed mice induced by chronic unpredictable mild stress (CUMS). BALB/c mice were divided into the following 5 groups (n = 12 in each group): (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 3 mg/kg), (4) CUMS + low dose of Jiaotai Pills group (stressor plus Jiaotai Pills treatment at the dose of 2.5 g/kg), and (5) CUMS + high dose of Jiaotai Pills group (stressor plus Jiaotai Pills treatment at the dose of 5 g/kg). The CUMS stress procedure lasted for 3 weeks, and drugs were administered via intragastric once per day for 2 weeks after stress. Liquid chromatography-tandem mass spectrometry was used to detect the levels of dopamine, 5-hydroxytryptamine, and norepinephrine in the hippocampus (n = 6/per group) and serum (n = 12/per group) of mice. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; BALB/c mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 60 |
Tissue | Central; Brain; Hippocampus; Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Agilent 1200 Liquid chromatography (Agilent, USA) with API 4000 tandem mass spectrometry (Sciex, USA); |
PMID | |
DOI | |
Citation | Dai GL, Yang XY, Chen SS, et al. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong Yao Za Zhi. 2021 Dec;46(24):6511-6519. (Article in Chinese) |
Metabolite |
