Study M885
Study name | Brivio P 2022 |
Title | Metabolomic signature and mitochondrial dynamics outline the difference between vulnerability and resilience to chronic stress |
Overall design | The aim of this study was to investigate whether a peculiar mitochondrial function and energetic metabolite profile contribute to dictate the difference between resilience or vulnerable phenotype in response to stress. Wistar rats were divided into the following 2 groups: (1) control group, and (2) chronic mild stress (CMS) group. The CMS stress procedure lasted for 2 weeks. On the basis of the result of the sucrose consumption test carried out following the first 2 weeks of stress, animals showing the anhedonic phenotype (CMS-vulnerable group) were separated by the animals that did not develop anhedonia despite CMS (CMS-resilient group). A targeted metabolomics was performed to investigate nucleotide, amino acid, biogenic amine, acylcarnitine, glycolysis and tricarboxylic acid cycle intermediate levels in ventral hippocampus of no stress, vulnerable, and resilient rats (n =3/per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 9 |
Tissue | Central; Brain; Ventral hippocampus; |
Platform | MS-based; LC-MS: ExionLC AC System (AB Sciex, Framingham, MA, USA) with API-3500 triple quadrupole mass spectrometer (AB Sciex, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Brivio P, Audano M, Gallo MT, et al. Metabolomic signature and mitochondrial dynamics outline the difference between vulnerability and resilience to chronic stress. Transl Psychiatry. 2022 Feb 28;12(1):87. |
Metabolite | Citric acid; L-Glutamic acid; Glycine; L-Serine; L-Lactic acid; L-Glutamine; Succinic acid; Isocitric acid; Citrulline; Guanosine triphosphate; Cytidine triphosphate; Uridine triphosphate; Fructose 1,6-bisphosphate; Guanosine monophosphate; Adenosine monophosphate; Inosinic acid; Carnitine C16:0; Acetyl-CoA; Uridine 5'-monophosphate; |
