Study M880
Study name | Wu J 2022 |
Title | Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model |
Overall design | The aim of this study was to characterize how gut virus and bacterial species, and associated metabolites change in depression-like monkey model. Cynomolgus monkeys were divided into the following 2 groups (n = 6 per group): (1) control group (cynomolgus macaques without depressive-like behavior), and (2) depression group (cynomolgus macaques with depressive-like behavior). Plasma, prefrontal cortex, amygdala, and hippocampus tissues were used for lipidomic analyses. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Non-human primate; Cynomolgus monkey; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Behavioral observation |
Sample size | 12 |
Tissue | Peripheral; Blood; Plasma; Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; Central; Brain; Amygdala; |
Platform | MS-based; LC-MS: Liquid chromatography with Thermo Scientific Q Exactive hybrid quadrupole Orbitrap mass spectrometer; |
PMID | |
DOI | |
Citation | Wu J, Chai T, Zhang H, et al. Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model. Transl Psychiatry. 2022 Feb 22;12(1):74. |
Metabolite | LysoPC(16:0); LysoPC(18:0); LysoPC(18:1); LysoPC(18:2); PC(34:2p); PC(40:7); PC(32:2); PC(34:3); PC(42:10); PC(18:0/20:4); PC(16:0/18:1); LysoPC(22:5); PE(18:1/23:1); PI(16:0/20:3); PI(16:0/20:4); PC(18:1/18:3); PI(18:1/20:4); SM(d18:2/16:0); SM(d18:2/18:0); LysoPE(22:4); N-stearoyl-sphingadienine; PC(40:8); PC(34:4); TG(53:3); PE(15:0/22:6); PE(18:1/20:4); PE(47:11); PE(47:13); PC(17:4/18:1); PC(44:11); PA(16:0/22:4); DG(36:3p); So(d16:1); PE(16:0p/22:5); PE(18:0p/20:3); PE(20:3/23:5); PE(37:1); PE(38:4e); PC(17:0/18:1); TG(16:0/18:1/18:2); TG(16:0/18:2/18:3); TG(18:0/16:0/18:2); TG(18:2/17:2/18:2); TG(53:7); DG(55:1); DG(55:2); PC(20:0/18:3); PC(37:6p); PE(17:0/22:4); PE(28:2/20:4); PE(26:0/21:4); PC(16:0/17:2); PC(16:0/20:5); PC(18:1p/20:4); PS(19:0/18:1); PA(24:2/20:4); |
