Study M878
Study name | Ryan KM 2020a |
Title | Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy |
Overall design | The aim of this study was to investigate B vitamin plasma concentrations in medicated patients with depression (n = 94) compared to age- and sex-matched healthy controls (control group, n = 57), and in patients with depression after electroconvulsive therapy (ECT) in a real-world clinical setting. The depression group included patients with unipolar depression (unipolar depression group, n = 73) and bipolar depression (bipolar depression group, n = 21). ECT was administered twice-weekly with hand-held electrodes. LC/MS was used to quantify circulating concentrations of thiamine (vitamin B1), thiamine monophosphate (vitamin B1 metabolite), riboflavin (vitamin B2), flavin mononucleotide (vitamin B2 metabolite), nicotinamide (vitamin B3), N1-methylnicotinamide (vitamin B3 metabolite), pyridoxal 50-phosphate (vitamin B6), pyridoxal (vitamin B6), and 4-pyridoxic acid (vitamin B6 catabolite). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-24 >= 21 |
Sample size | 130 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Ryan KM, Allers KA, Harkin A, et al. Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy. Brain Behav Immun Health. 2020 Mar 28;4:100063. |
Metabolite |
