Study M875
Study name | Ong SK 2021 |
Title | Integration of the cortical haemodynamic response measured by functional near-infrared spectroscopy and amino acid analysis to aid in the diagnosis of major depressive disorder |
Overall design | In the present study, the authors evaluated the differences between major depressive disorder (MDD) patients and healthy controls in terms of cortical haemodynamic responses during a verbal fluency test (VFT) using functional near-infrared spectroscopy (fNIRS) and serum amino acid profiles, and ascertained if these parameters were correlated with clinical characteristics. Patients with MDD (MDD group, n =25) and age-, gender-, and ethnicity-matched healthy controls (control group, n =25) were recruited for the study. Serum samples were analyzed and quantified by liquid chromatography-mass spectrometry for amino acid profiling. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD |
Sample size | 50 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC system (Agilent Technologies, Santa Clara, CA, USA) coupled with a quadrupole-ion trap mass spectrometer (QTRAP 5500, AB Sciex, Olympia, DC, USA); |
PMID | |
DOI | |
Citation | Ong SK, Husain SF, Wee HN, et al. Integration of the cortical haemodynamic response measured by functional near-infrared spectroscopy and amino acid analysis to aid in the diagnosis of major depressive disorder. Diagnostics (Basel). 2021 Oct 25;11(11):1978. |
Metabolite |
