Study M874
Study name | Lin H 2022 |
Title | Incompatible effects of Panax ginseng and Veratrum nigrum on estrogen decline in rats using metabolomics and gut microbiota |
Overall design | The aim of this study was to examine the incompatible effects of Panax ginseng and Veratrum nigrum on estrogen decline in rats to better understand the adverse effects of inappropriate herbal combinations using metabolomics and gut microbiota. Sprague-Dawley rats were divided into the following 3 groups: (1) control group (sham operation, n = 13), (2) ovariectomy group (ovariectomy operation, n = 13), and (3) ovariectomy + Panax ginseng group (ovariectomy plus 6 g/kg Panax ginseng decoction, intragastrically, n = 12). After 7 weeks of administration, behavioral experiments were performed on all rats. A urinary metabolomics method was applied. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 38 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: Waters Acquity UPLC liquid chromatography system, Q-TOF SYNAPT G2 HDMS mass spectrometer; |
PMID | |
DOI | |
Citation | Lin H, Liu Z, Liu Z, et al. Incompatible effects of Panax ginseng and Veratrum nigrum on estrogen decline in rats using metabolomics and gut microbiota. J Pharm Biomed Anal. 2022 Jan 20;208:114442. |
Metabolite | L-Valine; L-Glutamic acid; Pantothenic acid; |
