Study M864
Study name | Doss MK 2021 |
Title | Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder |
Overall design | In this study, the authors utilized multi-modal brain imaging measurements to examine the enduring effects of psilocybin therapy on cognitive and neural flexibility in patients with major depressive disorder (MDD). In an open-label study of 24 patients with MDD, participants were randomly assigned to an immediate treatment (psilocybin group, n = 13) and delayed treatment group (control group, n = 11), respectively. Participants attended two psilocybin sessions separated by ~1.6 weeks (session 1: 20 mg/70 kg; session 2: 30 mg/70 kg). Neurometabolite concentrations in the anterior cingulate cortex and hippocampus were detected before and after psilocybin treatment via magnetic resonance spectroscopy. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD, HAMD-17 >= 17 |
Sample size | 24 |
Tissue | Central; Brain; Anterior cingulate cortex; Central; Brain; Hippocampus; |
Platform | MRS; MRS: 7 T MRI (Philips Achieva, Best, The Netherlands); |
PMID | |
DOI | |
Citation | Doss MK, Povazan M, Rosenberg MD, et al. Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder. Transl Psychiatry. 2021 Nov 8;11(1):574. |
Metabolite |
