Study M863
Study name | Dang RZ 2022 |
Title | Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway |
Overall design | The aim of this study was to investigate the antidepressant activity of edaravone and its underlying mechanisms. A chronic social defeat stress (CSDS) depression model was performed to explore whether edaravone could produce antidepressant effects. C57BL/6J mice were divided into the following 3 groups (n = 10 in each group): (1) control group, (2) CSDS group (social defeat stress with vehicle treatment), and (3) CSDS + edaravone group (social defeat stress with edaravone treatment at the dose of 10 mg/kg). The CSDS stress procedure lasted for 10 days, and edaravone was administered intraperitoneally once per day for 10 days after the model building period. Hippocampal and medial prefrontal cortex tissues were collected for targeted energy metabolomics analysis (n = 6/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Sucrose preference test, social interaction test, forced swimming test, tail suspension test |
Sample size | 18 |
Tissue | Central; Brain; Medial prefrontal cortex; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC chromatography system and AB SCIEX 5500 QTRAP mass spectrometer; |
PMID | |
DOI | |
Citation | Dang R, Wang M, Li X, et al. Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway. J Neuroinflammation. 2022 Feb 7;19(1):41. |
Metabolite | Succinic acid; |
