Study M862
Study name | Chen YW 2021 |
Title | Early life stress induces different behaviors in adolescence and adulthood may related with abnormal medial prefrontal cortex excitation/inhibition balance |
Overall design | In this study, a series of behavioral tests, microdialysis, and whole-cell recordings were conducted on rats exposed to maternal separation to assess the effect of early life stress on the relationship between the excitation/inhibition imbalance of the medial prefrontal cortex (mPFC) and its behavioral deficits in adolescence and adulthood separately. Wistar rats were divided into the following 4 groups: (1) control adolescent group, (2) maternal separation adolescent group, (3) control adult group, and (4) maternal separation adult group. Maternal separation was conducted daily from postnatal day 1 (P1) to P20 for 4 h. For adolescent rats, behavioral tests were performed between P43 and P54. For adult rats, behavioral tests were performed between P82 and P93. In the dialysate of mPFC, GABA and glutamate were measured by HPLC with mass spectrometry (n = 5-7/per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 24 |
Tissue | Central; Brain; Medial prefrontal cortex; |
Platform | MS-based; LC-MS: Agilent 1200 Series separation module with 6410 triple quadrupole mass spectrometry; |
PMID | |
DOI | |
Citation | Chen Y, Zheng Y, Yan J, et al. Early life stress induces different behaviors in adolescence and adulthood may related with abnormal medial prefrontal cortex excitation/inhibition balance. Front Neurosci. 2022 Jan 4;15:720286. |
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